Zurnal Zdorovje

Contents

Molecular Biology

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Vol. 57, No. 2, 2023

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Bioinformatics and Systems Computer Biology

Molecular Mechanisms to Optimize Gene Translation Elongation Differ Significantly in Bacteria with and without Nonribosomal Peptides

A. I. Klimenko, S. A. Lashin, N. A. Kolchanov, D. A. Afonnikov and Yu. G. Matushkin p. 155  abstract

Primary and Secondary micro-RNA Modulation the Extrinsic Pathway of Apoptosis in Hepatocellular Carcinoma

T. M. Khlebodarova, P. S. Demenkov, T. V. Ivanisenko, E. A. Antropova, I. N. Lavrik and V. A. Ivanisenko p. 165  abstract

Geometric Approach to Phylogeographic Analysis Molecular Genetic Sequences: Principal Components and Dendrograms

V. M. Efimov, K. V. Efimov and V. Yu. Kovaleva p. 176  abstract

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Bioinformatics, Bioengineering, and Biotechnology

Comparative Analysis of Family A DNA-Polymerases as a Searching Tool for Enzymes with New Properties

A. A. Bulygin, A. A. Kuznetsova, O. S. Fedorova and N. A. Kuznetsov p. 182  abstract

Genotype-Specific Features of Cold-Induced Sweetening Process Regulation in Potato Varieties Nikulinsky, Symfonia, and Nevsky

A. A. Egorova, I. A. Saboiev, N. E. Kostina, D. D. Kuvaeva, A. B. Shcherban, S. M. Ibragimova, E. A. Salina and A. V. Kochetov p. 193  abstract

Modern Approaches to Protein Engineering to Create Enzymes with New Catalytic Properties

T. E. Tyugashev, O. S. Fedorova and N. A. Kuznetsov p. 204  abstract

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Systemic Pharmacology and Creation of New Medical Technologies

Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors In Vivo

T. E. Kornienko, A. L. Zakharenko, E. S. Ilina, A. A. Chepanova, O. D. Zakharova, N. S. Dyrkheeva, N. A. Popova, V. P. Nikolin, A. S. Filimonov, O. A. Luzina, N. F. Salakhutdinov and O. I. Lavrik p. 214  abstract

On Immunological Studies at Sirius University of Science and Technology

I. V. Astrakhantseva, V. G. Krut’, S. A. Chuvpilo, D. V. Shevyrev, A. N. Shumeev, S. A. Rybtsov and S. A. Nedospasov p. 225  abstract

Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy

E. A. Trifonova, A. A. Kotliarova and A. V. Kochetov p. 235  abstract

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Cell Molecular Biology: From DNA Repair to Metabolomics

Poly(ADP-Ribose) Polymerases 1 and 2: Classical Functions and Interaction with New Histone Poly(ADP-Ribosyl)ation Factor HPF1

T. A. Kurgina and O. I. Lavrik p. 245  abstract

Mechanisms of the Specificity of the CRISPR/Cas9 System in Genome Editing

L. M. Kulishova, I. P. Vokhtantsev, D. V. Kim and D. O. Zharkov p. 258  abstract

Influence of the Poly(ADP-Ribose) Polymerase 1 Level on the Status of Base Excision Repair in Human Cells

E. S. Ilina, A. S. Kochetkova, E. A. Belousova, M. M. Kutuzov, O. I. Lavrik and S. N. Khodyreva p. 272  abstract

Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration

D. V. Sherbakov, A. B. Arefieva, P. D. Komleva, A. E. Iz’urov, N. V. Khotskin, D. V. Bazovkina and A. V. Kulikov p. 284  abstract

Potential of Interferon Lambda as an Inhibitor of SARS-CoV-2

L. A. Oleinik, P. G. Madonov and M. B. Pykhtina p. 291  abstract

DNA Probes for Analysis of the Activity of Key Enzymes of the Base Excision DNA Repair Pathway in Human Cells

I. V. Alekseeva, A. A. Kuznetsova, O. A. Kladova, V. O. Shender, P. V. Schneider, O. S. Fedorova and N. A. Kuznetsov p. 299  abstract

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Structural-Functional Analysis of Biopolymers and Their Complexes

Factors Affecting the Stability of the Trimer of 2'-Deoxyuridine 5'-Triphosphate Nucleotide Hydrolase from Escherichia coli

A. V. Yudkina, E. A. Kovalenko, A. V. Endutkin, E. P. Panferova, A. A. Kirilenko, A. A. Kokhanenko and D. O. Zharkov p. 312  abstract

New Zwitter-Ionic Oligonucleotides: Preparation and Complementary Binding

D. E. Patrushev, E. A. Burakova, S. N. Bizyaev, A. A. Fokina and D. A. Stetsenko p. 320  abstract

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Evolutionary, Population, and Medical Genomics, Transcriptomics

Increased Frequencies of the ‒174G and ‒572C IL6 Alleles in Populations of Indigenous Peoples of Siberia Compared to Russians

L. E. Tabikhanova, L. P. Osipova, T. V. Churkina, S. S. Kovalev, M. L. Filipenko and E. N. Voronina p. 329  abstract

Profiling of Targeted miRNAs (8-nt) for the Genes Involved in Type 2 Diabetes Mellitus and Cardiac Hypertrophy

K. Hussain, A. Ishtiaq, I. Mushtaq and I. Murtaza p. 338  abstract

Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats

L. A. Fedoseeva, S. E. Smolenskaya, A. L. Markel and O. E. Redina p. 346  abstract

Changes in Expression of Genes Associated with Calcium Processes in the Hippocampus in Mice Exposed to Chronic Social Stress

M. B. Pavlova, D. A. Smagin, N. N. Kudryavtseva and N. A. Dyuzhikova p. 356  abstract

The P-Element Has Not Significant Effect on the Drosophila simulans Viability

L. P. Zakharenko, D. V. Petrovskii and R. A. Bykov p. 366  abstract